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AMD FirePro W4100 is a 4k-ready card and supports four monitors. It comes with 512 Stream Processors and 2GB GDDR5 memory. Based on something I read in another search, Windows 10 does allow for different brand GPU's to used at one time. This is a powerful midrange low profile professional graphics card from AMD. In the 4th PCIe x 16 slot I have a ASUS GT640-DCSL-2GD3 gpu that I have 3 of the Dell monitors hooked up to and it is working fine. I am using Windows 10 Pro 64 bit operating system. I did check the device manager but the second AMD Firepro W4100 did not show up. I could not get the second AMD Firepro W4100 to be recognized in either PCIe slot #2 or #3. No problem until I installed the Nvidia driver.
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But after moving to another computer (i7-6700, Windows 10, 16GB RAM, AMD Firepro W4100), I took my GTX 1050 to replace the crappy AMD GPU.
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So I unplugged two monitors from the first AMD Firepro W4100 in slot #1 that where working and hooked up two of the active adapters that I was trying to use on the second AMD Firepro W4100 in slot #2 to the working AMD Firepro W4100 in slot #1 and they worked fine, so that eliminates the adapter, cable and monitor being bad. We were suspecting an issue with a damaged partition on my SSD since launching a Windows from another HDD didn't cause any crash. I then tried it in PCIe x 16 slot #3 and it still did not work.
AMD FIREPRO W4100 CHROMA SETTING INSTALL
However when I went to install the second AMD Firepro W4100 into PCIe x 16 slot #2 it did not work. I installed the first AMD Firepro W4100 into PCIe x 16 slot #1 and it works fine. I have 8 active mini displayport to DVI adapters for my DVI cables made by Tripp Lite # P137-06N-DVI-V2. I am trying to hook up 10 Dell 2001 FP monitors. In this computer I have an Intel i7-4820K cpu and 32 GB's of DDR 3.0 RAM at 1600 ghz. I have a ASUS X79 Deluxe motherboard that has 4 PCIe X 16 slots.